TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN

DOI: 10.1016/S0040-4020(01)87656-0

Source and publish data:

Tetrahedron p. 4297 - 4308 (1986)

Update date:2022-08-03

Topics:

Authors:

Eyken, J. Van der

Clercq, P. de

Vandewalle, M.

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Article abstract of DOI:10.1016/S0040-4020(01)87656-0

A novel approach to (+/-)-epipodophyllotoxin (2c) and hence also to (+/-)-podophyllotoxin (1c) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 17a to the tetralin derivative 30c with mesyl chloride.

Full text of DOI:10.1016/S0040-4020(01)87656-0

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