One step synthesis of inverted aspartame type sweetener, Ac-Phe-Lys, using chemically modified chymotrypsin

Article abstract of DOI:10.1271/bbb.63.1156

To search for techniques of simplified peptide synthesis, benzyloxycarbonyl chymotrypsin was prepared by a water-soluble acylating reagent and used to make Ac-Phe-Lys, an artificial peptide sweetener, which was selected as a target compound. As a result o