Kinetic and mechanistic investigation of a hydrolytic catalytic antibody having remarkable substrate specificity: Substituent effects on catalysis

Article abstract of DOI:10.1246/bcsj.72.477

Monoclonal antibodies were raised against p-nitrophenyl phosphonate to elicit catalytic antibodies capable of hydrolyzing p-nitrophenyl carbonates. Of 34 clones selected, three clones catalyzed the hydrolysis of methyl p- nitrophenyl carbonate. Interestin