Nitration of phenols under mild and heterogeneous conditions

Article abstract of DOI:10.3390/60700614

Nitrophenols can be obtained in moderate to high yields using a combination of Mg(HSO₄)₂ or NaHSO₄.H₂O, NaNO₃ and wet SiO₂ in dichloromethane at room temperature.

Full text of DOI:10.3390/60700614

Molecules 2001, 6, 614-620
molecules
ISSN 1420-3049
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Nitration Of Phenols Under Mild And Heterogeneous
Conditions
Mohammad Ali Zolfigol*, Ezat Ghaemi, Elahe Madrakian
Department of Chemistry, College of Science, University of Bu-Ali Sina, Zip code 65174, P.O. Box
No. 4135, Hamadan, I.R. Iran, Fax: (+98) 811 8272404.
*Author to whom correspondence should be addressed; e-mail: Zolfi@basu.ac.ir
Received: 14 November 2000; in revised form 24 May 2001 / Accepted: 1 June 2001 / Published:
30 June 2001
Abstract: Nitrophenols can be obtained in moderate to high yields using a
combination of Mg(HSO4)2 or NaHSO4.H2O, NaNO3 and wet SiO2 in
dichloromethane at room temperature.
Keywords: Nitration; Phenols; Heterogeneous conditions; Inorganic acidic salts
Introduction
The nitration of aromatic compounds may be achieved with many nitrating reagents and is a
very useful method in organic synthesis [1]. Also, nitro compounds find use in many industrial
applications [2-4]. Nitration of phenol as a special case has been studied using various nitrating
agents under different conditions [4-22]. Recently, in this connection we have reported the use and
reaction mechanisms of some hydrated metal nitrates (containing covalent nitrato groups) and their
dinitrogen tetroxide complex analogues for the nitration of phenols under various conditions [23].
Our goal, in undertaking this line of work, is two-fold: (a) to overcome the limitations and
drawbacks of the reported methods such as tedious work-up [9-11], strongly acidic media (Ho~ -8)
[4b], oxidation ability of the reagents and safety problems (storage, handling, use and also the

615
Molecules 2001, 6
presence of poisonous transition metal cations such as Cr+3, Hg+2, Cu+2, etc. within the molecular
structures of the reagents ) [24, 25]; (b) moreover, constraining a reagent to the surface of a solid
usually allows the use of milder conditions and increases its reactivity [26]. Very recently, we and
others have demonstrated that heterogeneous reagent systems have many advantages such as simple
experimental procedures, mild reaction conditions and minimization of chemical wastes as
compared to their liquid phase counterparts [27]. Consequently, we decided to seek a heterogeneous
system for the nitration of phenol, and we have investigated a number of different reaction
conditions based upon the in situ generation of HNO3 by solid inorganic acidic salts
[NaHSO4·H2O, Mg(HSO4)2, pka~2 ] with sodium nitrate. We report here a one-pot heterogeneous
procedure for nitration of phenols.
Results and Discussion
Phenol (1) and different types of 4-substituted phenols (4) were subjected to a nitration reaction
in the presence of inorganic acidic salts [e.g. Mg(HSO4)2 (I) or NaHSO4·H2O (II)], NaNO3 (III),
and wet SiO2 (50% w/w) in dichloromethane (Schemes 1 and 2). The nitration reactions were
performed under mild and heterogeneous conditions at room temperature to give the products in
moderate to excellent yields (Table 1).
Scheme 1
OH
OH
OH
NO2
I or II
III
+
NO2
1
2
3
The nitration reactions can be readily carried out by placing the nitrating agents, phenols (1 or
4) and the solvent used in a reaction vessel and efficiently stirring the resultant heterogeneous
mixture at room temperature. The resulting mononitrophenols can be obtained by simple filtration
and evaporation of the solvent. This alternative method thus provides nitrated phenols directly, in
short reaction times and good yields.
Scheme 2
OH
OH
NO2
I or II
III
X
X
5
4

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Molecules 2001, 6
4
a
b
c
X
F
4
e
f
X
Ph
4
i
X
COOH
Cl
Br
CN
CH3
CH2Ph
j
OCH3
COCH3
NHOAc
4-HOC6H4-
g
h
k
l
d
In fact, a combination of sodium nitrate and inorganic acidic salts (I or II) can act as a solid
HNO3 equivalent which can be readily handled and used for different purposes in the presence of
wet SiO2 [28].
A competitive reaction between phenols and anisole was also performed. It was observed that
exclusive phenol nitration proceeded, whereas anisole is remained intact in the reaction mixtures
after 24 hours (Scheme 3).
Scheme 3
OH
OCH3
OCH3
OH
I or II
III
NO2
NO2
+
+
X
100%
0%
1
This method is also very mild as indicated by the fact that the hydrolysis product of 4-cyano-
phenol was not observed (Scheme 4, Table 1, entries 9 and 10). Selective mononitration of 4,4’-
dihydroxydiphenyl (4l) was also achieved by controlling the stoichiometry of the reagents (Table 1,
entries 25 and 26).
Scheme 4
OH
CN
OH
OH
NO2
NO2
I or II
III
+
CN
COOH
0%
100%

617
Molecules 2001, 6
Table 1. Substrates and Products
Reag. /Subst. (mmol)b
Time
Yieldsc
%
26
36
20
50
54
60
70
72
78
70
88
92
90
92
72
78
84
79
74
79
80
83
91
91
55
74
56
63
Entry Substrate Productsa
I
II
--
1
III
(Min)
2[7]
3[7]
1
2
1
1
30
30
1
1
2[7]
--
1
3[7]
5a[4]c
3
1
--
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
2
2
2
2
2
2
1
1
1
1
1
90
90
4a
4a
4b
4b
4c
4c
4d
4d
4e
4e
4f
4
--
1
5a[4c]
5
--
1
90
5b[11, 18]
5b[11, 18]
5c[11, 18]
5c[11, 18]
5d[11, 18]
5d[11, 18]
5e[11, 18]
5e[11, 18]
5f[11, 18]
5f[11, 18]
5g[18]
6
--
1
90
7
--
1
130
130
180
180
180
180
180
180
45
8
--
1
9
--
1
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
--
1
--
1
--
1
--
1
--
1
4f
--
1
4g
4g
4h
4h
4i
--
2
45
5g[18]
--
2
120
120
90
5h[11, 18]
5h[11, 18]
5i[18]
--
2
--
2
--
2
90
4i
5i[18]
--
2
180
180
180
180
90
4j
5j[18]
--
--
1
4j
5j[18]
1
4k
4k
4l
5k[22]
--
1
5k[22]
--
1
5l[21]
--
--
90
4l
5l[21]
--
No Reactiond
1
2, 3
a All of the isolated products are known compounds and their spectra and
physical data have been reported in the literature; b Wet SiO2 : substrate
c
d
(1) (0.2 g : 1 mmol); Isolated pure Yields; Nitration did not occur in
the absence of inorganic acidic salts.
Although the nitration reaction also occurs in the absence of wet SiO2, the reaction times are
very long and the reactions only go to completion after several days. Therefore, we think that the

618
Molecules 2001, 6
wet SiO2 acts as a reaction medium providing a heterogeneous effective surface area for in situ
generation of HNO3 in low concentrations. It also makes work-up easy. On the other hand, nitration
did not occur in the absence of the inorganic acidic salts (Table 1, entry 27).
Conclusions
In conclusion, the low cost and the availability of the reagents, easy and clean work-up, and
high yields make this an attractive method for Organic Synthesis. This simple procedure is highly
selective and contamination by oxidation side-products is avoided. Moreover, a key new feature is
the heterogeneous nature of the reaction, which could be worthwhile in an industrial setting [26].
Acknowledgments
The authors gratefully acknowledge partial support of this work by the Research Affairs Office
of Bu-Ali Sina University, Hamadan, I.R Iran.
Experimental section
General
Chemicals were purchased from the Fluka, Merck and Aldrich chemical companies. Melting
points were taken on a Gallenkamp melting point apparatus and are uncorrected. Proton and carbon
nuclear magnetic resonance spectra were recorded on a JEOL NMR-Spectrometer FX 90Q. IR
spectra were recorded on a Shimadzu 435 IR spectrophotometer. Thin layer chromatography (TLC)
on commercial aluminium-backed plates of silica gel 60 F254 was used to monitor the progress of
the reactions. Yields refer to isolated pure products. The nitration products were characterized by
1
comparison of their spectral (IR, H-NMR, 13C-NMR), TLC and physical data with authentic
samples.
Typical Procedure for Mononitration of Phenol (1) with Mg(HSO4)2 (I), NaNO3 (III) and wet SiO2
A suspension of compound 1 (1.88 g, 0.02 mol), I (4.40 g, 0.02 mol), III (1.7 g, 0.02 mol) and
wet SiO2 (50% w/w, 4 g) in CH2Cl2 (20 mL) was stirred magnetically at room temperature. The
reaction was complete after 30 min. and the reaction mixture was then filtered. The residue was
washed with CH2Cl2 (2x10 mL). Anhydrous Na2SO4 (10 g) was added to the combined filtrate and
washings. After 15 minutes the mixture was filtered. The solvent was removed by distillation using
a water bath (35-40°C). The residue is a mixture of 2- and 4-nitrophenol, which may be purified by
addition of n-pentane as the latter is insoluble in this solvent. Yield of 4-nitrophenol (2): 1.44 g,
26%, mp 112-113 °C {lit [7] mp 114 °C}. The n-pentane was evaporated on a water bath (35-40
°C) to give the 2-nitrophenol (3): 2 g, 36%, mp 43-45 °C {lit. [7] mp 44 °C}.

619
Molecules 2001, 6
Typical Procedure for Mononitration of 4-Cyanophenol (4d) with Mg(HSO4)2 (I), NaNO3 (III) and
wet SiO2
A suspension of compound 4d (0.238 g, 2 mmol), I (0.44 g 2 mmol), wet SiO2 (50% w/w, 0.4 g)
and III (0.17 g, 2 mmol) in dichloromethane (4 mL) was stirred at room temperature for 3 hours
(the progress of the reaction was monitored by TLC) and then filtered. Anhydrous Na2SO4 (5 g)
was added to the filtrate. After 15 minutes the resulting mixture was also filtered. Dichloromethane
was removed by simple distillation using a water bath (35-40 °C). The yield was 0.288 g, (88%) of
o
o
1
crystalline pale yellow solid (5d), mp 143-144 C,{Lit. [4c] mp 145 C}. H-NMR (FT-90 MHz,
1
CDCl3, TMS): δ 7.34 (d, 1H), 7.77 (dd, 1H), 8.48 (d, 1H), 10.87 (b, 1H). H-NMR spectra were
identical with reference spectra [4c].
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