A convenient one pot procedure for N-methylation of aromatic amines using trimethyl orthoformate

Article abstract of DOI:10.1080/00397919708003343

Aromatic amines react with trimethyl orthoformate in the presence of concentrated sulfuric acid followed by acid hydrolysis to afford mono methylated amines in moderate to good yields.

Full text of DOI:10.1080/00397919708003343

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Synthetic Communications:
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A Convenient One Pot
Procedure for N-Methylation
of Aromatic Amines Using
Trimethyl Orthoformate
Seetharamaiyer Padmanabhan a , N. Laxma
Reddy a & Graham J. Durant a
a Cambridge NeuroScience Inc., One Kendall
Square, Building #700, Cambridge, MA, 02139,
U.S.A.
Version of record first published: 20 Aug 2006.
To cite this article: Seetharamaiyer Padmanabhan , N. Laxma Reddy & Graham
J. Durant (1997): A Convenient One Pot Procedure for N-Methylation of
Aromatic Amines Using Trimethyl Orthoformate, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
27:4, 691-699
To link to this article: http://dx.doi.org/10.1080/00397919708003343
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