A convenient one-step method for converting electron-rich aromatic aldehydes into nitriles

DOI: 10.1055/s-1992-26185

Source and publish data:

Synthesis p. 641 - 642 (1992)

Update date:2022-08-11

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Authors:

Suzuki Suzuki

Nakaya Nakaya

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Article abstract of DOI:10.1055/s-1992-26185

Electron-rich aromatic aldehydes react with sodium azide in the presence of aluminum chloride in boiling tetrahydrofuran to give the corresponding nitriles in good yields, while electron-deficient or hindered aromatic aldehydes lead to (diazidomethyl) arenes in moderate yield under similar conditions.

Full text of DOI:10.1055/s-1992-26185

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