The chemistry of acylals. Part II. Formation of nitriles by treatment of acylals with trimethylsilyl azide in the presence of a lewis acid

DOI: 10.1016/S0040-4039(98)01309-4

Source and publish data:

Tetrahedron Letters p. 6361 - 6364 (1998)

Update date:2022-08-16

Topics:

Authors:

Sandberg, Marcel

Sydnes, Leiv K.

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Article abstract of DOI:10.1016/S0040-4039(98)01309-4

When acylals from aliphatic and aromatic aldehydes are treated with trimethylsilyl azide in the presence of titanium(IV) chloride, the latter group of compounds is converted to the corresponding nitriles in good to excellent yields. By-products were not formed.

Full text of DOI:10.1016/S0040-4039(98)01309-4

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