An efficient one-pot synthesis of nitriles from carboxylic acids without solvent under microwave irradiation

Article abstract of DOI:10.1080/00397919608004778

Nitriles were prepared from alkyl and aryl carboxylic acids in dry media conditions, under microwave irradiation. Heating of the carboxylic acid, urea and amidosulfonic acid adsorbed on alumina support in a microwave oven affords nitriles in 20-93% yields.

Full text of DOI:10.1080/00397919608004778

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Efficient One-Pot Synthesis
of Nitriles from Carboxylic
Acids Without Solvent Under
Microwave Irradiation
Feng Juncai a , Liu Bin a , Liu Yang a & Li Changchuan
b
a Department of Chemistry, Nanjing University,
Nanjing, 210093, P.R. China
b Nanjing Food Processing and Packaging Machinery
Institute, Nanjing, 210029, P.R. China
Version of record first published: 21 Aug 2006.
To cite this article: Feng Juncai , Liu Bin , Liu Yang & Li Changchuan (1996): An
Efficient One-Pot Synthesis of Nitriles from Carboxylic Acids Without Solvent Under
Microwave Irradiation, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 26:24, 4545-4548
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FENG ET AL.
4546
The
route is
as follows:
RCOOH +
+ CO, +
2
3
microwave irradiation
or
The results
are shown
Table I.
1 7
13
7 2
79
13