Microwave Induced Synthesis of 3,4-Dihydro-2H-pyran-2-carboxaldehyde: A Versatile Linker for Solid Phase Combinatorial Library

Article abstract of DOI:10.1002/jccs.199700092

Procedures for the dimerization of acrolein to form 3,4-dihydro-2H-pyran-2-carboxaldehyde by microwave induced synthesis have been developed. Significant rate-enhancement and yield increase were observed. 3,4-Dihydro-2H-pyran-2-carboxaldehyde was obtained in 91% yield under microwave irradiation for 5 minutes instead of 39% yield by reacting at 190 °C for 40 min or at 160 °C for 4 hr.