Kinetics of Oxidation of Amino Acids by Chloramine-T. A Reinvestigation on the Oxidation of Alanine, 2-Aminobutyric Acid, Valine, Serine, and Threonine

Article abstract of DOI:10.1246/bcsj.60.3397

The kinetics of oxidation of amino acids in aqueous medium were reinvestigated.The rate of oxidation follows second order with respect to chloramine-T (CAT) and an inverse dependence on (RNH2).At constant the rate of the reaction can be represented as (in the absence of chloride ion) .A linear relationship exists between pK₁ and the rate constants.This shows the electrophilic attack of the oxidant at the carboxylato group of the amino acid.The effect of chloride ion on k_obsd is catalytic.The mechanisms of the reactions are discussed in terms of the kinetic results.