A short synthesis of astemizole

Article abstract of DOI:10.1080/00397919608004642

The synthesis of astemizole 6, a potent H₁-antihistaminic agent, was achieved in 20% overall yield. Compound 6 was obtained in high purity and on a multigram scale starting from 2-hydroxybenzimidazole.

Full text of DOI:10.1080/00397919608004642

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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A Short Synthesis of Astemizole
Cecilia Anaya deParrodi a , Leticia Quintero-Cortés b
& Jesús Sandoval-Ramírez b
a Depto. de Química y Biología , Universidad de
las Américas-Puebla , Sta. Catarina Mártir, 72820,
Cholula, Pue., México
b Centro de Investigación, Facultad de Ciencias
Químicas, Universidad Autónoma de Puebla ,
Puebla, 72570, Pue. México
Published online: 21 Aug 2006.
To cite this article: Cecilia Anaya deParrodi , Leticia Quintero-Cortés & Jesús
Sandoval-Ramírez (1996) A Short Synthesis of Astemizole, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
26:17, 3323-3329, DOI: 10.1080/00397919608004642
To link to this article: http://dx.doi.org/10.1080/00397919608004642
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