β,γ-Unsaturated α-amino ester derivatives by amination of γ-silylated α,β-unsaturated esters

Article abstract of DOI:10.1016/S0040-4020(97)10045-X

The reactions of γ-silylated α,β-unsaturated esters 3a-3 and 6 with NsONHCO₂Et and CaO, produce β,γ-unsaturated N-(ethoxycarbonyl) α-amino esters 4a-e and 8, isolated in 38-66% yield, through addition of (ethoxycarbonyl)aminic function on the double bond and silyl group elimination. The reactivity increases in presence of α-substituents.