An expeditious and practical synthetic process for phytosphingosine and tetrahydroxy-LCB from D-glutamic acid

Article abstract of DOI:10.1016/0957-4166(96)00254-6

For the asymmetric synthesis of phytosphingosine and 2-amino-1,3,4,5-tetrahydroxyoctadecene, the long chain base (LCB) part of novel cerebrosides, a simple and short synthetic route is described featuring the elabortion of the functionalized homochiral lactam derived from D-glutamic acid as a common structural unit.