Kinetic Asymmetric Protonation as a Stereochemistry Determining Step in the Michael Addition of Acetic Acid Derivatives to α-Substituted Cinnamic Acid Derivatives

Article abstract of DOI:10.1007/BF00811020

The reaction between acetic acid derivatives and α-substituted cinnamic acid derivatives has been studied in THF and THF:HMPT (80:20) as an alternative pathway of the Michael addition of phenylacetic and cinnamic acid derivatives.The regioselectivity obse