Heterocycles p. 1565 - 1569 (2006)
Update date:2022-08-29
Topics:
Somei, Masanori
Iwaki, Takako
Yamada, Fumio
Tanaka, Yoshio
Shigenobu, Koki
Koike, Katsuo
Suzuki, Nobuo
Hattori, Atsuhiko
According to the definition of the ideal synthetic method, an example aimed at the leads for an α2 blocker, an inhibitor of platelet aggregation, and an anti-osteoporosis agent is established starting from tryptamine. The originality rate, the intellectual property, and the application potential factors of the method are 71, 54, and 100, respectively. The method employs only conventional reagents and reaction conditions without using any protecting groups.{A figure is presented}.
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Doi:10.1039/d0gc03070h
(2021)Doi:10.1021/jo051609r
(2006)Doi:10.1055/s-2008-1077957
(2008)Doi:10.1039/c9tc01397k
(2019)Doi:10.1021/ja00865a022
(1962)Doi:10.1002/hlca.19760590814
(1976)