Synthesis of functionally substituted unsymmetrical biaryls via a novel double metal catalyzed coupling reaction

Article abstract of DOI:10.1016/S0040-4039(98)01587-1

Unsymmetrical biaryls containing 'reactive' functional groups (e.g., nitrile or ester groups) can be synthesized in an efficient manner by the direct Ni- or Pd-catalyzed coupling of aryl halides (X = Cl, Br, I) with aryl Grignard (or -lithium) reagents, provided that a catalytic amount of a Zn or Cd salt is also present.