Reactions of Sodium Borohydride in Acidic Media; XVI. N-Methylation of Amines with Paraformaldehyde/Trifluoroacetic Acid

DOI: 10.1055/s-1987-28053

Source and publish data:

Synthesis p. 709 - 711 (1987)

Update date:2022-08-24

Topics:

Authors:

Gribble, Gordon W.

Nutaitis, Charles F.

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Article abstract of DOI:10.1055/s-1987-28053

Primary and secondary amines are N-methylated to afford tertiary amines with the combination of paraformaldehyde, sodium borohydride, and trifluoroacetic acid.

Full text of DOI:10.1055/s-1987-28053

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