Selective deoxygenation of amine N-oxides using borohydride exchange resin-copper sulfate in methanol

Article abstract of DOI:10.1055/s-1996-4221

Borohydride exchange resin-copper sulfate in methanol readily deoxygenates quantitatively both tertiary amine N-oxides and heteroaromatic N-oxides at room temperature or under reflux. It tolerates many functional groups such as carbon-carbon double bond, chloride, epoxide, ester, amide, nitrile, sulfoxide, sulfone, and aliphatic disulfide moieties.