5
Conclusions
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In conclusion, we have developed the first and expedient zinc-
catalyzed methodology for the tandem Sonogashira-type
coupling-cyclization reactions. It is presumed that the reaction
proceeds first through a Sonogashira cross-coupling reaction by
an in situ generated Zn–DMEDA complex followed by base
promoted cyclization. Our protocol tolerates a broad range of
functional groups and can be used for the synthesis of varieties of
both substituted benzofurans and indoles. The present method is
efficient in terms of yield, catalyst loading, reaction conditions
and catalyst toxicity. The simplicity of this reaction protocol
makes it a feasible alternative to the commonly employed routes
in heterocycle synthesis. To the best of our knowledge, the
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2
present report is the first example of a practical use of Et Zn in
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respective o-iodo phenol and o-iodo aniline.
3
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GA thanks the Kerala State Council for Science, Technology
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thanks the KSCSTE for a junior research fellowship. SKS and
SMU thank UGC for junior research fellowships. We thank the
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Intensive Research in Basic Sciences (IIRBS) of Mahatma
Gandhi University for HRMS and NMR facilities respectively.
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Supplementary data
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