A novel phosphitylating reagent for in situ generation of deoxyribonucleoside phosphoramidites

DOI: 10.1016/0040-4039(95)02165-5

Source and publish data:

Tetrahedron Letters p. 331 - 334 (1996)

Update date:2022-08-17

Topics:

Authors:

Zhang, Zhaoda

Tang, Jin Yan

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Article abstract of DOI:10.1016/0040-4039(95)02165-5

A new phosphitylating reagent, 2-cyanoethoxy(N,N-diisopropylamino)3-nitro-1,2,4-triazolylphosphine (1), has been prepared and effectively used in in situ generation of 5'-DMT-nucleoside phosphoramidites and automated syntheses of oligonucleotides.

Full text of DOI:10.1016/0040-4039(95)02165-5

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Product name:5'-O-(4,4'-Dimethoxytrityl)-N4-benzoyl-2'-deoxycytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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