Beilstein Journal of Organic Chemistry p. 19 - 25 (2017)
Update date:2022-08-11
Topics:
Mascitti, Andrea
Lupacchini, Massimiliano
Guerra, Ruben
Taydakov, Ilya
Tonucci, Lucia
D'Alessandro, Nicola
Lamaty, Frederic
Martinez, Jean
Colacino, Evelina
The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under drygrinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents. In general, cleaner reaction profiles were observed in the presence of PEGs, compared to dry-grinding procedures.
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