Resolution of (1,1'-Binaphthalene)-2,2'-dithiol by Enzyme Catalysed Hydrolysis of a Racemic Diacyl Derivative

Article abstract of DOI:10.1016/S0040-4020(01)85237-6

Both enantiomers of (1,1'-binaphthalene)-2,2'-dithiol (1) can be obtained with 98percent ee by enzymatic (cholesterol esterase) resolution of the corresponding S,S'-dipentanoate.Absolute configuration and enantiomeric purity were determined by crystal structure and 1H NMR analysis, respectively, of a diastereomeric derivative of 1.