Lipase-catalyzed resolution of 2-azabicyclo[2.2.1]hept-5-en-3-ones

DOI: 10.1016/0957-4166(96)00293-5

Source and publish data:

Tetrahedron Asymmetry p. 2381 - 2386 (1996)

Update date:2022-08-28

Topics:

Authors:

Nakano, Hiroto

Iwasa, Kazuto

Okuyama, Yuko

Hongo, Hiroshi

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Article abstract of DOI:10.1016/0957-4166(96)00293-5

The lipase-catalyzed asymmetric resolution of 2-azabicyclo[2.2.1]hept-5-en-3-ones is reported; non-racemic chiral 2-azabicyclo[2.2.1]hept-5-en-3-ones were obtained conveniently by lipase-catalyzed enantioselective transesterification or hydrolysis of N-hydroxymethyl-2-azabicyclo[2.2.1]hept-5-en-3-one or N-acyloxymethyl-2-azabicyclo[2.2.1]hept-5-en-3-one.

Full text of DOI:10.1016/0957-4166(96)00293-5

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