Tetrahedron p. 7761 - 7768 (1993)
Update date:2022-08-30
Topics:
Guijarro, David
Yus, Miguel
The lithiation of different phenone imines 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in the presence of several carbonyl compounds 2 in tetrahydrofuran at temperatures ranging between -78 and 20°C leads, after hydrolysis with water, to the corresponding 1,2-aminoalcohols 3 in moderate yields.
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(1979)
