Organic Process Research and Development p. 1841 - 1851 (2019)
Update date:2022-08-28
Topics:
Hejazifar, Mahtab
Pálv?lgyi, ádám Márk
Bitai, Jacqueline
Lanaridi, Olga
Bica-Schr?der, Katharina
A thermomorphic ionic-liquid-based microemulsion system was successfully applied for the Ru-catalyzed asymmetric transfer hydrogenation of ketones. On the basis of the temperature-dependent multiphase behavior of the targeted microemulsion, simple product separation as well as catalyst recycling could be realized. The use of water-soluble ligands improved the immobilization of the catalyst in the microemulsion phase and significantly decreased the catalyst leaching into the organic layer upon extraction of the product. Eventually, the optimized microemulsion system could be applied to a wide range of aromatic ketones that were reduced with good isolated yields (up to 98%) and enantioselectivities (up to 97%), while aliphatic ketones were less successful.
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