Catalytic enantioselective addition of diethylzinc to aldehydes: Synthesis and application of a new cyclic catalyst

Article abstract of DOI:10.1016/S0957-4166(00)80328-6

The new optically active b-amino alcohol (S)-1-methyl-2-(diphenylhydroxymethyl)azetidine (S)-4 derived from (S)-azetidinecarboxylic acid (S)-1 catalyzes the enantioselective addition of diethylzinc to various aldehydes. The resulting chiral secondary alco