Sialidase inhibitors related to zanamivir: Synthesis and biological evaluation of 4H-pyran 6-ether and ketone

DOI: 10.1016/S0960-894X(99)00031-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 601 - 604 (1999)

Update date:2022-08-16

Topics:

Authors:

Smith, Paul W.

Robinson, J.Ed

Evans, Derek N.

Sollis, Steven L.

Howes, Peter D.

Trivedi, Naimisha

Bethell, Richard C.

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Article abstract of DOI:10.1016/S0960-894X(99)00031-1

Synthesis of 5R-Acetamido-4S-amino-4H-pyran-6R-O-(1-ethyl)propyl and 6R- (1-oxo-2-ethyl)butyl 2-carboxylic acids (4 and 5) and their evaluation as inhibitors of influenza virus sialidase is described. Both compounds showed good inhibitory activity with ma

Full text of DOI:10.1016/S0960-894X(99)00031-1

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Product name:5H-Pyrano[3,2-d]oxazole-5-methanol, 6,7-bis(acetyloxy)-3a,6,7,7a-tetrahydro-2-methyl-, acetate (ester)

Cas No:10378-06-0

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