Activation of Reducing Agents. Sodium Hydride Containing Complex Reducing Agents. 13. Selective Heterogeneous Hydrogenation of Polyfunctional Substrates over Nic

Article abstract of DOI:10.1021/jo01298a037

Preparative-scale heterogeneous hydrogenation over Nic at room temperature and 1 atm are described.It is shown that these catalysts allow the selective hydrogenation of carbon-carbon double bonds in the presence of oxo groups without side reactions.Alkynes and functional alkynes are selectively hydrogenated to the corresponding cis alkenes in high yields.Carbonyl group hydrogenations were also performed in high yields.Selective hydrogenation properties of Nic were exemplified in the steroid series.Finally, it was demonstrated that this new catalyst-preparation concept is not limited to nickel and also applies to the preparation of cobalt and palladium catalysts.