Preparation of oligomeric 2'-deoxy-5-fluorouridylate of defined length and backbone composition: A novel pro-drug form of the potent anti-cancer drug 2'-deoxy-5-fluorouridylate

Article abstract of DOI:10.1080/15257779508014667

A recursive protection scheme for FdUMP is employed by synthesizing oligonucleotides consisting of only FdU. 3'-O-exonuclease action releases FdUMP and a shortened oligonucleotide from which further exonuclease action releases more FdUMP. Such oligonucleo

Full text of DOI:10.1080/15257779508014667

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Nucleosides and Nucleotides
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Preparation of Oligomeric 2′-Deoxy-5-
Fluorouridylate of Defined Length and
Backbone Composition: A Novel Pro-
Drug form of the Potent Anti-Cancer
Drug 2′-Deoxy-5-Fluorouridylate
William H. Gmeiner a b , Parag Sahasrabudhe a b , Richard T.
Pon d , Jacque Sonntag c , Shashikumar Srinivasan c & Patrick L.
Iversen a c
a Eppley Cancer Institute, Omaha, University of Nebraska
Medical Center , Omaha, NE, 68198-6805
b Department of Pharmaceutical Sciences , University of
Nebraska Medical Center , Omaha, NE, 68198-6805
c Department of Pharmacology , University of Nebraska Medical
Center , Omaha, NE, 68198-6805
d Regional DNA Synthesis Laboratory , University of Calgary
Published online: 24 Sep 2006.
To cite this article: William H. Gmeiner , Parag Sahasrabudhe , Richard T. Pon , Jacque Sonntag ,
Shashikumar Srinivasan & Patrick L. Iversen (1995) Preparation of Oligomeric 2′-Deoxy-5-
Fluorouridylate of Defined Length and Backbone Composition: A Novel Pro-Drug form of the
Potent Anti-Cancer Drug 2′-Deoxy-5-Fluorouridylate, Nucleosides and Nucleotides, 14:1-2,
243-253, DOI: 10.1080/15257779508014667
To link to this article: http://dx.doi.org/10.1080/15257779508014667
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