Total synthesis of (±)-(Z)-9-(Bromomethylene)-1,5,5-trimethylspiro[5.5]undeca-1,7-dien- 3-one, a brominated sesquiterpene of the chamigrane type

Article abstract of DOI:10.1016/S0040-4020(01)96126-5

(±)-(Z)-9-(Bromomethylene)-1,5,5-trimethylspiro[5.5]undeca-1,7-dien-3 -one (1), a chamigrane sesquiterpene having a novel bromomethylene group is synthesized from anisole via spiroannelation of 4-(1,1-dimethyl-4-formylbutyl)-3-cyclohexen-1-one (10).