Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives

DOI: 10.1021/jm00391a034

Source and publish data:

Journal of Medicinal Chemistry p. 1482 - 1489 (1987)

Update date:2022-08-16

Topics:

Authors:

Wentland

Bailey Bailey

Alexander

Castaldi

Ferrari Ferrari

Haubrich

Luttinger

Perrone Perrone

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Article abstract of DOI:10.1021/jm00391a034

A unique combination of α₂-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4,5-dihydro-1H-imidazole derivatives. This combination of blocking activities has provided one of these derivatives, napamezole hydrochloride (2), with potential as an antidepressant. A discussion of the syntheses of these compounds includes a convenient method for the conversion of nitriles to imidazolines with ethylenediamine and trimethylaluminum.

Full text of DOI:10.1021/jm00391a034

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