Asymmetric reduction of aromatic ketones. II. An enantioselective synthesis of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate

DOI: 10.1248/cpb.41.643

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 643 - 648 (1993)

Update date:2022-08-22

Topics:

Authors:

Matsuki Matsuki

Sobukawa

Kawai Kawai

Inoue Inoue

Takeda Takeda

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Article abstract of DOI:10.1248/cpb.41.643

Asymmetric reduction of some 3-keto esters (6, 8, and 11) to 3-hydroxy esters (7, 9, and 12) with various chiral reducing agents was investigated. The products (9 and 12) were converted to methyl (2R,3S)-3-(4-methoxyphenyl)glycidate (2R,3S-3), a key intermediate in the practical enantioselective synthesis of diltiazem (1).

Full text of DOI:10.1248/cpb.41.643

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Product name:METHYL (2R,3S)-2,3-EPOXY-3-(4-METHOXYPHENYL)PROPIONATE

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