A STABLE 1:1 LITHIUM ACYLCYANOCUPRATE. DEPENDENCE OF THE STABILITY OF ACYLCYANOCUPRATES ON THE NATURE OF THE ALKYL SUBSTITUENT.

Article abstract of DOI:10.1016/S0040-4039(00)84288-4

Acylcuprates obtained by carbonylation of R(CN)CuLi cuprates (R=t-Bu, sec-Bu) at low temperature are effective in the direct nucleophilic 1,4-acylation of α,β-unsaturated ketones and aldehydes.The R=t-Bu reagent is sufficiently stable so that it can be us