Hypervalent iodine oxidation of silyl enol ethers under Lewis acid conditions in methanol. A general route to α-methoxy ketones

DOI: 10.1021/jo00377a027

Source and publish data:

Journal of Organic Chemistry p. 150 - 153 (1987)

Update date:2022-08-30

Topics:

Authors:

Moriarty, Robert M.

Prakash, Om

Duncan, Michael P.

Vaid, Radhe K.

Musallam, Hikmat A.

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Article abstract of DOI:10.1021/jo00377a027

Hypervalent iodine oxidation of various silyl enol ethers (aromatic, heteroaromatic, aliphatic) using iodosobenzene-boron trifluoride etherate in methanol leads to α-methoxylation of ketones in high yields. The scope and mechanism of the reaction are discussed.

Full text of DOI:10.1021/jo00377a027

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