Novel Oxidative Pathway of para-Substituted Phenols in Cytochrome P450 Chemical Model: Substituent Elimination Accompanying ipso-Substitution by the Oxygen Atom of the Active Species

Article abstract of DOI:10.1016/0040-4039(95)01611-K

The meso-tetrakis(2,6-difluorophenyl)porphinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols.An experiment using <¹⁸O>mCPBA proved that these reactions are accompanied with ipso-substitution by the oxygen atom of the active species of the P450 model.