Bioorganic and Medicinal Chemistry Letters p. 2853 - 2856 (1997)
Update date:2022-08-28
Topics:
Abell, Andrew D.
Hoult, Deborah A.
Bergman, Douglas A.
Fairlie, David P.
The 4-nitrophenoxy-based epoxide 6a, conveniently synthesized using Sharpless epoxidation chemistry, has been shown to be an irreversible inhibitor of HIV-1 protease (k(inact) 1.8 μM, pH 6.5, I = 0.1 M). Related analogues, differing in the mode of attachm
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(1997)
