Acylation of diethyl phosphonoacetic acid via the MgCl2/Et3N system: A practical synthesis of β-keto phosphonates

Article abstract of DOI:10.1080/00397910008087362

A one pot simple procedure for the synthesis of β-keto phosphonates has been developed using the MgCl₂/Et₃N base system to generate the magnesium enolate of diethyl phosphonoacetic acid. This intermediate reacts with acid chlorides or imidazolides to give, after workup, the title compounds in good yields.

Full text of DOI:10.1080/00397910008087362

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Synthetic Communications: An
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Organic Chemistry
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Acylation of Diethyl
Phosphonoacetic Acid Via
the MgCl2/Et3N System: A
Practical Synthesis of β-Keto
Phosphonates
Bernard Corbel a , Isabelle L'hostis-Kervella a & Jean-
Pierre Haelters a
a Laboratoire de Chimie Hétéro-Organique, U.F.R.
Sciences, Université de Bretagne Occidentale, B.P.
809, F-29285, Brest Cedex
Published online: 04 Dec 2007.
To cite this article: Bernard Corbel , Isabelle L'hostis-Kervella & Jean-Pierre
Haelters (2000) Acylation of Diethyl Phosphonoacetic Acid Via the MgCl2/Et3N
System: A Practical Synthesis of β-Keto Phosphonates, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 30:4,
609-618, DOI: 10.1080/00397910008087362
To link to this article: http://dx.doi.org/10.1080/00397910008087362
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