Biological and Pharmaceutical Bulletin p. 265 - 267 (1999)
Update date:2022-08-17
Topics:
Lee, Im Seon
Jung, Keun Young
Oh, Sei Ryang
Park, Si Hyung
Ahn, Kyung Seop
Lee, Hyeong-Kyu
We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1 x 10-6 M) in this study.
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