Product Enantioselectivity of the Microsomal and Cytosolic Epoxide Hydrolase catalysed Hydrolysis of meso Epoxides

DOI: 10.1039/c39890001170

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1170 - 1171 (1989)

Update date:2022-08-11

Topics:

Authors:

Bellucci, Giuseppe

Capitani, Isabella

Chiappe, Cinzia

Marioni, Franco

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Article abstract of DOI:10.1039/c39890001170

1,2-Epoxycycloalkanes from C5 to C8 and cis-stilbene oxide are respectively hydrolysed to the corresponding (-)-(R,R)-trans-diols and to (+)-(R,R)-1,2-diphenylethane-1,2-diol by both the microsomal and the cytosolic epoxide hydrolase of rabbit liver, the former enzyme being more active and giving higher enantiomeric excesses.

Full text of DOI:10.1039/c39890001170

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