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2003 Marcel Dekker, Inc. All rights reserved. This material may not be used or reproduced in any form without the express written permission of Marcel Dekker, Inc.
1
24
Wang et al.
g: M.p. 200–202 C; IR (KBr, ꢀ, cm ): 3300, 3200, 3040, 2990,
ꢀ
ꢁ1
3
1
2
970, 2240, 1680, 1600, 1450, 770; H NMR (CD COCD , ꢁ, ppm):
3 3
1.08 (3H, s, CH ), 1.10 (3H, s, CH ), 2.20 (2H, s, CH ), 2.54 (2H, s,
CH ), 3.05 (2H, br., s, NH ), 4.86 (1H, s, CH), 7.29 (4H, s, ArH); MS:
3
3
2
2
2
þ
m/e (%) 328 (M , 4), 293 (15), 227 (100), 211 (34), 171 (80), 136 (11), 115
7); Elemental analysis: Found (%): C, 65.92; H, 5.18; N, 8.43. Calcd. for
C H ClN O : C, 65.75; H, 5.21; N, 8.52.
(
1
8
17
2
2
ꢀ
ꢁ1
3
h: M.p. 130–132 C; IR (KBr, ꢀ, cm ): 3300, 3200, 3040, 2990,
1
2
970, 2240, 1650, 1600, 1510, 830; H NMR (CD COCD , ꢁ, ppm):
3 3
1.00 (3H, s, CH ), 1.10 (3H, s, CH ), 2.20 (2H, s, CH ), 2.60 (2H, s,
CH ), 3.06 (2H, br., s, NH ), 4.49 (1H, s, CH), 7.26–8.29 (4H, m,
3
3
2
2
2
þ
ArH); MS: m/e (%) 339 (M , 20), 242 (100), 217 (35), 186 (14), 145
(
20), 117 (15); Elemental analysis: Found (%): C, 63.95; H, 4.98; N,
1
2.27. Calcd. for C H N O : C, 63.71; H, 5.05; N, 12.38.
18 17 3 4
ꢀ
ꢁ1
3
i: M.p. 218–220 C; IR (KBr, ꢀ, cm ): 3400, 3300, 3050, 2990, 2980,
1
2
240, 1680, 1600, 730; H NMR (CD COCD , ꢁ, ppm): 1.00 (3H, s,
3
3
CH ), 1.10 (3H, s, CH ), 2.28 (2H, s, CH ), 2.54 (2H, s, CH ), 3.05
3
3
2
2
(
(
2H, br., s, NH ), 4.44 (1H, s, CH), 6.18–7.37 (3H, m, ArH); MS: m/e
2
%) 284 (M , 4), 256 (11), 218 (100), 203 (30), 190 (35), 162 (69), 134 (48),
þ
1
9
20 (30), 106 (35); Elemental analysis: Found (%): C, 67.62; H, 5.54; N,
.79. Calcd. for C H N O : C, 67.59; H, 5.67; N, 9.86.
1
6
16
2
3
ꢀ
ꢁ1
3j: M.p. 146–148 C, IR (KBr, ꢀ, cm ) 3410, 3270, 3020, 2980, 1700,
1
2
660, 1610, 1500, 1450, 740, 710; ꢁ 0.96 (3H, s, CH ), 1.09 (3H, s, CH ),
H
3
3
.19 (2H, s, CH ), 2.42 (2H, s, CH ), 3.60 (3H, s, OCH ), 4.72 (1H, s,
3
2
2
CH), 6.16 (2H, br., s, NH ), 7.22 (5H, s, ArH); Elemental analysis: Found
2
(
N, 4.28.
%): C, 69.52; H, 6.57; N, 4.20. Calcd. for C H NO : C, 69.72; H, 6.42;
19 21 4
ꢀ
ꢁ1
3k: M.p. 158–160 C, IR (KBr, v, cm ) 3400, 3260, 3020, 2980, 1700,
1
660, 1610, 1520, 1460, 730, 700; ꢁH 0.93–1.23 (9H, m, 3 Â CH ), 2.15
3
(
2H, s, CH ), 2.38 (2H, s, CH ), 3.82–4.18 (2H, q, J ¼ 7.2 Hz, OCH ),
2
2
2
4.67 (1H, s, CH), 6.04 (2H, br., s, NH ), 7.17 (5H, s, ArH); Elemental
analysis: Found (%): C, 70.27; H, 6.84; N, 4.08. Calcd. for C H NO :
2
2
0
23
4
C, 70.38; H, 6.74; N, 4.11.
ꢀ
ꢁ1
3
l: M.p. 172–174 C, IR (KBr, ꢀ, cm ) 3310, 3260, 3020, 2980, 1730,
1
700, 1610, 1510, 1460, 840; ꢁ 0.97 (3H, s, CH ), 1.09 (3H, s, CH ), 2.18
H 3 3
(
2H, s, CH ), 2.26 (3H, s, CH ), 2.41 (2H, s, CH ), 3.60 (3H, s, OCH ),
2 3 2 3
4.68 (1H, s, CH), 6.10 (2H, br., s, NH ), 7.06–7.10 (4H, m, ArH);
2
Elemental analysis: Found (%): C, 70.33; H, 6.90; N, 4.05. Calcd. for
C H NO : C, 70.38; H, 6.74; N, 4.11.
2
0
23
4
ꢀ
ꢁ1
3m: M.p. 156–157 C, IR (KBr, ꢀ, cm ) 3300, 3250, 3020, 2980,
1
720, 1690, 1610, 1500, 1470, 830; ꢁH 0.98–1.29 (9H, m, 3 Â CH ), 2.19
3