Tetrahedron Letters p. 4611 - 4614 (1986)
Update date:2022-08-16
Topics:
Tomioka, Kiyoshi
Yasuda, Kosuke
Koga, Kenji
Utilizing the L-valine-based chiral lithioenamine (5) of ethyl acetoacetate (1), enantioface differentiating Michael reaction with alkylidenemalonates (2) gave, after decarboxylation, β-substituted δ-keto esters (3) in a fair to godd enantiomeric excess.Kinetic diastereoenrichment of the initial Michael adducts (7) was also studied.Combination of both processes provides the procedure for the synthesis of 3 in 55-93percent ee.
View More
MedicalChem(Yancheng)Manuf.Co.,Ltd.
Contact:+86-515-84383366
Address:Touzeng BinHai, YanCheng City, JiangSu Province, China
Shanghai Kangxin Chemical Co., Ltd
Contact:+86 21 60717227
Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
Jiande City Silibase Silicone New Material Manufacture Co., Ltd.
Contact:15967177856
Address:Genglou Industrial Development Area
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Zhuzhou Farshine Chemical Industry Co., Ltd
Contact:0086-731-28482786
Address:No. 1,Shui Xian Road, He Tang Dictrict,Hunan-412000,China
Doi:10.1055/s-1986-31810
(1986)Doi:10.1021/jo00979a015
(1972)Doi:10.1002/adsc.200800207
(2008)Doi:10.1002/anie.200802611
(2008)Doi:10.1016/j.bmc.2008.09.001
(2008)Doi:10.1021/jo00389a047
(1987)
