Synthesis of D-erythro-sphingosine and D-erythro sphinganine via 3- ketosphinganine

Article abstract of DOI:10.1016/S0040-4039(98)00733-3

D-erythro- sphingosine and D-erythro-sphinganine can be produced in protected form from serine by a synthetic approach in which the normal biological intermediate 3-ketosphinganine in protectyed form, is a key synthetic intermediate. The sequence is short and convergent, proceeds in good overall yields (? 30% for 6 steps) and with excellent stereocontrol (>91% de, >95% ee).