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M. Yao et al.
Letter
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I
I
I
2aa
2an
2ba
379.2 mg, 81%
415.0 mg, 91%
562.5 mg, 95%
2.0131 g, 86%
2.1663 g, 95%
2.7827 g, 94%
O
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OEt
I
2bd
I
2az
466.1 mg, 91%
2.4072 g, 94%
403.2 mg, 90%
2.0384 g, 91%
Figure 1 A scale-up synthesis of 1-iodoalkynes
species could be easily converted into 1-iodoalkynes via the
deprotonation of alkynes facilitated by AcO– along with the
release of acetic acid.
OH
N
OH
N
O
AcOH
AcO
I
I
N
I
O
O
O
AcO
I
H
R
A
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I
OAc
R
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Scheme 3 A plausible mechanism for AcOH-mediated iodination of
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Funding Information
We are grateful to the Hubei Provincial Department of Education
(T201719) for generous financial support.
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Supporting Information
Supporting information for this article is available online at
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