Diastereoselective synthesis of α-bromoamides leading to diastereomerically enriched α-amino-, α-hydroxy- and α-thiocarboxylic acid derivatives

Article abstract of DOI:10.1016/0957-4166(94)00360-N

α-Bromoamides derived from bornane-10,2-sultam can be prepared diastereoselectively starting from racemic α-bromo acids, and undergo epimerisation under appropriate conditions leading to an enhanced d.e. By reacting the individual isomers, or in some case