Regioselective hydrolysis of cocaine and a convenient acylation procedure by benzoylecgonine

Article abstract of DOI:10.1080/00397919708005651

Regioselective hydrolysis of cocaine led, according to the reaction conditions, either to benzoylecgonine or to ecgonine methyl ester. Acylation with benzoylecgonine was readily achieved when benzotriazolyloxytrisdimethylaminophosphonium (BOP) was used as a coupling agent.

Full text of DOI:10.1080/00397919708005651

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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Regioselective Hydrolysis of
Cocaine and A Convenient
Acylation Procedure by
Benzoylecgonine
a
a
a
F. Martinet , Ch. Pham Huy , A. Tomas , J. M.
b
a
Scherrmann & H. Galons
a
Laboratoire de Chimie Organique Faculté de
Pharmacie , 4 avenue de l'Observatoire, 75270,
Paris, France
b
Hopital Fernand Widal , 200 rue du Faubourg Saint
Denis, 75010, Paris, France
Published online: 22 Aug 2006.
To cite this article: F. Martinet , Ch. Pham Huy , A. Tomas , J. M. Scherrmann &
H. Galons (1997) Regioselective Hydrolysis of Cocaine and A Convenient Acylation
Procedure by Benzoylecgonine, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 27:19, 3485-3490, DOI:
10.1080/00397919708005651
To link to this article: http://dx.doi.org/10.1080/00397919708005651
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