Synthesis of Benzimidazole Derivatives
2927
agent under mild and heterogeneous conditions. Catal. Commun. 2007, 8,
427–1430.
4 2
2. Niknam, K.; Zolfigol, M. A.; Sadabadi, T. Ca (HSO ) mediated conversion
of alcohols into N-substituted amides under heterogeneous conditions: A
modified ritter reaction. J. Iran. Chem. Soc. 2007, 4, 199–204.
3. See review about metal hydrogen sulfates: Shirini, F.; Zolfigol, M. A.; Salehi,
P.; Abedini, M. Application of some metal hydrogen sulfates in organic
transformations. Curr. Org. Chem. 2008, 12, 183–202.
4. Zarrinmayeh, H.; Nunes, A. M.; Ornstein, P. L.; Zimmerman, D. A.;
Gackenheimer, S. L.; Bruns, R. F.; Hipskind, P. A.; Britton, T. C.; Cantrell,
B. E.; Gehlert, D. R. Synthesis and evaluation of a series of novel 2-[(4-chlor-
ophenoxy)methyl]-benzimidazoles as selective neuropeptide Y Y1 receptor
antagonists. J. Med. Chem. 1998, 41, 2709–2719.
1
1
1
1
1
1
1
5. Nakano, H.; Inoue, T.; Kawasaki, N.; Miyataka, H.; Matsumoto, H.;
Taguchi, T.; Inagaki, N.; Nagai, H.; Satoh, T. Synthesis and biological activi-
ties of novel antiallergic agents with 5-lipoxygenase inhibiting action. Bioorg.
Med. Chem. 2000, 8, 373–380.
6. Zhao, Z. S.; Arnaiz, D. O.; Griedel, B.; Sakata, S.; Dallas, J. L.; Whitlow, M.;
Trinh, L.; Post, J.; Liang, A.; Morrissey, M. M.; Shaw, K. J. Design, syn-
thesis, and in vitro biological activity of benzimidazole based factor Xa inhi-
bitors. Bioorg. Med. Chem. Lett. 2000, 10, 963–966.
7. White, A. W.; Almassy, R.; Calvert, A. H.; Curtin, N. J.; Griffin, R. J.;
Hostomsky, Z.; Maegley, K.; Newell, D. R.; Srinivasan, S.; Golding, B. T.
Resistance-modifying agents, 9.1: Synthesis and biological properties of
benzimidazole inhibitors of the DNA repair enzyme poly (ADP-ribose) poly-
merase. J. Med. Chem. 2000, 43, 4084–4097.
1
8. Zhu, Z.; Lippa, B.; Drach, J. C.; Townsend, L. B. Design, synthesis, and bio-
logical evaluation of tricyclic nucleosides (dimensional probes) as analogues
of certain antiviral polyhalogenated benzimidazole ribonucleosides. J. Med.
Chem. 2000, 43, 2430–2437.
1
2
9. Spasov, A. A.; Yozhitsa, I. N.; Bugaeva, L. I.; Anisimova, V. A. Benzimida-
zole derivatives: Spectrum of pharmacological activity and toxicological
properties. Pharm. Chem. J. 1999, 33, 232–243.
0. Evans, B. E.; Rittle, K. E.; Bock, M. G.; Dipardo, R. M.; Freidinger, R. M.;
Whitter, W. L.; Lundell, G. F.; Veber, D. F.; Anderson, P. S.; Chang, R. S.;
Chang, R. S. L.; Lotti, V. J.; Gerino, D. J.; Chen, T. B.; Kling, P. J.; Kunkel,
K. A.; Springer, J. P.; Hirshfield, J. Methods for drug discovery: Develop-
ment of potent, selective, orally effective cholecystokinin antagonists. J.
Med. Chem. 1988, 31, 2235–2246.
2
2
2
1. Perston, P. N. Chemistry of Heterocyclic Compounds; A. Weissberger, E. C.
Taylor (Eds.); John Wiley and Sons, 1981; Vol. 40.
2. Chi, Y.-C.; Sun, C.-M. Soluble polymer-supported synthesis of a benzimida-
zole library. Synlett 2000, 591–594.
3. Huang, W.; Scarborough, R. M. A new ‘‘traceless’’ solid-phase synthesis
strategy: Synthesis of a benzimidazole library. Tetrahedron Lett. 1999, 40,
2665–2668.