BIOCATALYTIC RESOLUTION OF (+/-)-HYDROXYALKANOIC ESTERS. A STRATEGY FOR ENHANCING THE ENANTIOMERIC SPECIFICITY OF LIPASE-CATALYZED ESTER HYDROLYSIS.

Article abstract of DOI:10.1016/S0040-4039(00)80643-7

A general biocatalytic procedure for the preparation of a variety of R- and S-hydroalkanoic esters of high optical purity has been developed.The noteworthy feature of this methodology resides in the selection of a nonhydrolyzable ester at the carboxyl terminus to improve the enantiospecificity in the lipase-catalyzed hydrolysis of the acyloxy ester.