Chemoenzymatic synthesis of macrocyclic polyamines

Article abstract of DOI:10.1016/S0040-4039(99)00954-5

(±)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cyclization of (±)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small number of hydroxy-azaesters using this biocatalytic approach.