
Tetrahedron Letters p. 4965 - 4968 (1999)
Update date:2022-08-16
Topics:
Lu, Wei
Sih, Charles J.
(±)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cyclization of (±)-hydroxy-azaesters. Further, the size of the macrocyclic lactones formed could be altered by the substituent on the nitrogen atom. This allows one to prepare a combinatorial library of azamacrolides from a small number of hydroxy-azaesters using this biocatalytic approach.
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