Synthesis and biological properties of some novel heterocyclic homoprostanoids

Article abstract of DOI:10.1021/jm00245a009

In the search for prostaglandin like structures capable of exerting specific and desirable biological properties, a variety of simple heterocyclic homoprostanoidal derivatives was synthesized from readily available stearic acid derivatives Compounds 5b and 5e were found to be more than 100 times as potent as PGE₁ and PGE₂ in a tracheal chain bioassay and, like 6, 9, and 12, inhibited PGE₂ induced diarrhea. Derivatives 6 and 7a showed significant PG synthetase inhibitor activity.