A Comparative Investigation of the Reactions of α-Metallomethyl Isocyanides with α,β-Unsaturated Ketones

Article abstract of DOI:10.1055/s-1987-27957

The nucleophilic addition of lithiomethyl isocyanide to representative α,β-unsaturated ketones has been examined.The ratio of 1,2- to 1,4-addition is dependent upon the inclusion of ligating cosolvents.In addition, the reactions of alternative α-metallomethyl isocyanides with α,β-unsaturated ketones have been studied.